Cajun Chicken Rotini with Mozzarella Garlic Butter Sauce is an irresistible dish that combines the bold flavors of Cajun seasoning with creamy mozzarella and garlic butter. Perfect for family dinners or gatherings, this recipe stands out due to its rich taste and ease of preparation. You’ll love how effortlessly it comes together, making it a go-to meal for any occasion.
Why You’ll Love This Recipe
- Bold Flavor – The blend of Cajun seasoning and garlic creates a delightful punch that will tantalize your taste buds.
- Creamy Texture – The mozzarella and heavy cream make for a rich, velvety sauce that clings perfectly to each rotini spiral.
- Quick Preparation – In just 35 minutes, you can serve up a delicious meal that feels gourmet without the fuss.
- Family-Friendly – With its comforting flavors, this dish appeals to both kids and adults, making it a hit at the dinner table.
- Versatile Serving Options – Enjoy it as a main dish or as a side at your next barbecue or gathering.
Tools and Preparation
Before diving into the cooking process, gather your essential tools. Having everything ready makes the cooking experience smoother and more enjoyable.
Essential Tools and Equipment
- Large pot
- Skillet
- Measuring cups and spoons
- Knife and cutting board
- Serving spoon
Importance of Each Tool
- Large pot – Essential for boiling pasta efficiently, ensuring it’s cooked evenly.
- Skillet – Ideal for sautéing chicken and creating the rich sauce; its non-stick surface helps prevent sticking.
- Measuring cups and spoons – Accurate measurements are key for balancing flavors in this recipe.
- Knife and cutting board – A good knife paired with a sturdy cutting board makes preparing ingredients quick and safe.

Ingredients
For the Chicken
- 1 lbs boneless, skinless chicken breasts, cut into bite-sized pieces
- 2 tbsp olive oil
- 3 tbsp unsalted butter, divided
- 1 tsp Cajun seasoning, adjust to taste
- Salt and black pepper, to taste
For the Pasta
- 12 oz rotini pasta
For the Sauce
- 4 cloves garlic, minced
- 1 cup heavy cream
- 1 cup shredded mozzarella cheese
- 1 cup freshly grated Parmesan cheese
- 1 tsp Italian seasoning
- Crushed red pepper flakes, to taste
- Fresh chopped parsley, for garnish
How to Make Cajun Chicken Rotini with Mozzarella Garlic Butter Sauce
Step 1: Boil the Pasta
Boil a large pot of salted water. Add the rotini and cook until al dente—about 9 to 10 minutes. Reserve ½ cup of the pasta water, then drain and set aside.
Step 2: Prepare the Chicken
Season the chicken pieces with Cajun seasoning, salt, and pepper. Toss until evenly coated.
Step 3: Sear the Chicken
Heat olive oil and 1 tablespoon of butter in a large skillet over medium-high heat. Add the chicken and sear for 7-8 minutes until golden brown and cooked through. Stir occasionally. In the last minute, stir in half of the minced garlic to infuse flavor. Remove chicken from skillet and set aside.
Step 4: Make the Sauce
Lower the heat to medium. Add the remaining 2 tablespoons of butter to the same skillet along with the rest of the garlic. Sauté for about 30 seconds until fragrant.
Step 5: Add Cream
Pour in the heavy cream while stirring as it heats up. Let it simmer for about 2-3 minutes to thicken slightly.
Step 6: Incorporate Cheeses
Stir in both mozzarella and Parmesan cheeses. Mix well until melted into a thick, velvety sauce.
Step 7: Season It Up
Season your sauce with Italian seasoning, crushed red pepper flakes (if using), salt, and pepper to taste.
Step 8: Combine Pasta
Add cooked rotini to the skillet, tossing until all spirals are coated with that creamy Cajun cheese sauce. If needed, add a splash of reserved pasta water to loosen up the sauce.
Step 9: Serve Hot
Serve your cheesy rotini hot with Cajun garlic chicken spooned on top or folded in. Garnish with fresh parsley and extra cheese if desired.
How to Serve Cajun Chicken Rotini with Mozzarella Garlic Butter Sauce
Serving Cajun Chicken Rotini with Mozzarella Garlic Butter Sauce can elevate your dining experience. Here are some creative serving ideas to enhance this flavorful dish.
Pairing Suggestions
- Fresh Garden Salad: A light salad with mixed greens, cherry tomatoes, and a simple vinaigrette complements the richness of the pasta.
- Garlic Bread: Crunchy garlic bread is perfect for soaking up any leftover sauce on your plate.
- Grilled Vegetables: Charred veggies like zucchini and bell peppers add a smoky flavor that balances the creamy sauce.
- Roasted Asparagus: Tender asparagus spears provide a delightful crunch and fresh taste alongside the rotini.
- Coleslaw: A tangy coleslaw adds a refreshing crunch that contrasts nicely with the creamy cheese sauce.
Garnishing Ideas
- Chopped Parsley: Fresh parsley not only adds color but also brings a bright, herbaceous note to your dish.
- Extra Cheese: A sprinkle of additional mozzarella or Parmesan on top makes it even more indulgent.
How to Perfect Cajun Chicken Rotini with Mozzarella Garlic Butter Sauce
To achieve the best results with your Cajun Chicken Rotini, consider these helpful tips for cooking and flavor enhancement.
- Bold seasoning: Don’t be shy with your Cajun seasoning; adjust according to your taste preferences for a more robust flavor.
- Quality ingredients: Use fresh garlic and high-quality cheeses for the best taste in your sauce.
- Pasta water magic: Reserve some pasta water before draining; it helps to adjust the sauce consistency if needed.
- Sear chicken properly: Ensure the chicken pieces are seared well for added texture and flavor before mixing them into the sauce.
- Stir continuously: When adding cheese to the cream sauce, stir constantly for a smooth and creamy texture without lumps.
Best Side Dishes for Cajun Chicken Rotini with Mozzarella Garlic Butter Sauce
Pairing side dishes with Cajun Chicken Rotini enhances your meal’s overall appeal. Here are some excellent options to consider.
- Steamed Broccoli: Lightly steamed broccoli adds color and nutrition, balancing out the richness of the pasta.
- Corn on the Cob: Sweet corn provides a nice contrast in flavor; grill it or boil it for an easy side.
- Caesar Salad: A classic Caesar salad adds crunch and creaminess that complements the dish perfectly.
- Baked Sweet Potatoes: Their natural sweetness pairs well with spicy flavors, offering a satisfying starch option.
- Roasted Baby Potatoes: Crispy potatoes seasoned with herbs make for a hearty side that everyone loves.
- Quinoa Salad: A chilled quinoa salad loaded with vegetables offers a refreshing option next to warm pasta.
Common Mistakes to Avoid
Cooking Cajun Chicken Rotini with Mozzarella Garlic Butter Sauce can be a delightful experience, but there are some common mistakes to steer clear of.
- Skipping the seasoning: Failing to season the chicken adequately can lead to bland flavors. Make sure to coat the chicken evenly with Cajun seasoning and adjust according to your taste.
- Overcooking the rotini: Cooking pasta too long results in mushy texture. Keep an eye on the rotini and aim for al dente, which usually takes about 9-10 minutes.
- Not reserving pasta water: Forgetting to save some pasta water can affect the sauce’s consistency. Reserve a cup before draining, as it helps loosen the sauce if needed.
- Using low-quality cheese: Using subpar cheese can lead to a less creamy texture and flavor. Opt for fresh mozzarella and good-quality Parmesan for the best results.
- Ignoring garlic timing: Adding garlic too early can burn it, resulting in bitterness. Always add minced garlic in the last minute of cooking for a fragrant flavor boost.

Storage & Reheating Instructions
Refrigerator Storage
- Store leftovers in an airtight container.
- Consume within 3-4 days for best quality.
Freezing Cajun Chicken Rotini with Mozzarella Garlic Butter Sauce
- Allow the dish to cool completely before freezing.
- Use freezer-safe containers or bags and consume within 2-3 months.
Reheating Cajun Chicken Rotini with Mozzarella Garlic Butter Sauce
- Oven: Preheat to 350°F (175°C), cover with foil, and heat for about 20 minutes or until warmed through.
- Microwave: Place in a microwave-safe dish, cover, and heat on medium power for 2-3 minutes, stirring halfway through.
- Stovetop: Heat on medium-low in a skillet; add a splash of reserved pasta water if needed, stirring until hot.
Frequently Asked Questions
Here are some frequently asked questions about making Cajun Chicken Rotini with Mozzarella Garlic Butter Sauce.
Can I use other types of pasta?
Yes! You can substitute rotini with penne or fusilli if you prefer different shapes while maintaining similar cooking times.
How do I make this dish spicier?
To increase heat, add more Cajun seasoning or include crushed red pepper flakes when mixing the sauce. Adjust based on your spice tolerance!
Can I make this recipe vegetarian?
Absolutely! Substitute chicken with sautéed mushrooms or tofu and use vegetable broth instead of chicken broth for a tasty vegetarian version.
What should I serve with Cajun Chicken Rotini with Mozzarella Garlic Butter Sauce?
This dish pairs well with a simple green salad or garlic bread for a complete meal that balances flavors well.
Final Thoughts
Cajun Chicken Rotini with Mozzarella Garlic Butter Sauce is not only rich and creamy but also versatile enough to adapt to various tastes. Feel free to customize it by adding vegetables like spinach or bell peppers! Give this recipe a try, and enjoy its delightful flavors any night of the week.

Cajun Chicken Rotini with Mozzarella Garlic Butter Sauce
- Total Time: 35 minutes
- Yield: Serves 4
Description
Cajun Chicken Rotini with Mozzarella Garlic Butter Sauce is a vibrant, mouthwatering dish that effortlessly combines the kick of Cajun spices with the creaminess of a rich garlic butter sauce. This recipe features tender chicken and rotini pasta enveloped in a velvety blend of mozzarella and Parmesan cheeses, making it a perfect choice for family dinners or casual gatherings. In just 35 minutes, you can create a satisfying meal that’s sure to impress everyone at the table. Whether enjoyed on a weeknight or served at a special occasion, this dish is both comforting and bursting with flavor.
Ingredients
- 1 lb boneless, skinless chicken breasts
- 12 oz rotini pasta
- 2 tbsp olive oil
- 3 tbsp unsalted butter
- 1 tsp Cajun seasoning
- Salt and black pepper to taste
- 4 cloves garlic, minced
- 1 cup heavy cream
- 1 cup shredded mozzarella cheese
- 1 cup grated Parmesan cheese
- 1 tsp Italian seasoning
- Crushed red pepper flakes to taste
- Fresh chopped parsley for garnish
Instructions
- Boil salted water in a large pot and cook the rotini until al dente (9-10 minutes). Reserve ½ cup of pasta water before draining.
- Season chicken with Cajun seasoning, salt, and pepper.
- Heat olive oil and 1 tbsp butter in a skillet over medium-high heat, add chicken, and sear for 7-8 minutes. Stir in half of the minced garlic during the last minute. Remove from skillet.
- Lower heat, add remaining butter and garlic to the skillet, stirring until fragrant.
- Pour in heavy cream and simmer for 2-3 minutes.
- Stir in mozzarella and Parmesan until melted into a sauce.
- Season with Italian seasoning, crushed red pepper flakes (if using), salt, and pepper.
- Toss cooked rotini into the sauce, adding reserved pasta water as needed for consistency.
- Serve hot topped with Cajun chicken and garnished with parsley.
- Prep Time: 10 minutes
- Cook Time: 25 minutes
- Category: Main Course
- Method: Stovetop
- Cuisine: Cajun
Nutrition
- Serving Size: 1 serving
- Calories: 650
- Sugar: 4g
- Sodium: 890mg
- Fat: 38g
- Saturated Fat: 21g
- Unsaturated Fat: 15g
- Trans Fat: 0g
- Carbohydrates: 48g
- Fiber: 3g
- Protein: 36g
- Cholesterol: 130mg